;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; GLOBAL VARIABLES ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; globals [ ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;; Nicotinic Acetylcholine receptors ;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; k1 ; association rate at first site k-1 ; dissociation rate of first site k2 ; association rate at second site k-2 ; dissociation rate of second site b1 ; opening rate with one ligand a1 ; closing rate with one ligand b2 ; opening rate with two ligands a2 ; closing rate with two ligands bD ; desensitization rate with two ligands aD ; resensitization rate with two ligands ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;; Acetylcholinesterase ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ke ; association rate of substrate k-e ; dissociation rate of substrate kcat ; catalytic turnover rate kinh ; inhibitor association rate constant kage ; inhibitor aging constant kact ; activator on-rate k-act ; activator off-rate ;eps-on ; activation coefficient for enzyme binding substrate eps-off ; activation coefficient for enzyme releasing substrate ;eps-cat ; activation coefficient for enzyme catalysis ;eps-inh ; activation coefficient for inhibitor binding ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;; Agent Accounting ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; sumOpen ; total number of open NARs = instantaneous signal sumAllOpen ; total number NARs opened ever (total signal produced) sumC ; total number of Cholines produced nC ; number of choline nA ; number of ACh nI ; number of inhibitors nAct ; number of activators ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;; Run Control ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; dt ; time step dtp ; time step-print tend ; end of simulation time time ; time ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;; Environmental Settings ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; Vol ; volume (nm3) As0 ; initial amount of ACh Ain ; amount of ACh per injection Diff ; diffusion coeffecient (nm2/s) ] ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; BREED DEFINITIONS ;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; breed [ Rs R ] ; unbound NARs breed [ ARs AR ] ; closed monoliganded NARs breed [ A2Rs A2R ] ; closed diliganded NARs breed [ AOs AO ] ; open monoliganded NARs breed [ A2Os A2O ] ; open diliganded NARs breed [ A2Ds A2D ] ; desensitized NARs breed [ tEns tEn ] ; unbound pre-synaptic AChE breed [ AtEs AtE ] ; bound pre-synaptic AChE breed [ As A ] ; free ACh breed [ Cs C ] ; free choline breed [ bEns bEn ] ; unbound post-synaptic AChE breed [ AbEs AbE ] ; bound post-synaptic AChE breed [ A-ins A-in ] ; new ACh for signal injections breed [ Inhs Inh ] ; inhibitors breed [ ItEs ItE ] ; inhibited pre-synaptic enyzme breed [ IbEs IbE ] ; inhibited post-synaptic enzyme breed [ Ageds Aged ] ; aged enzymes breed [ Acts Act ] ; activators breed [ ActEs ActE ] ; activated pre-synaptic enzyme breed [ AcbEs AcbE ] ; activated post-synaptic enzyme breed [ AcAtEs AcAtE ] ; activated, substrate bound pre-synaptic enzyme breed [ AcAbEs AcAbE ] ; activated, substrate bound post-synaptic enzyme breed [ AcItEs AcItE ] ; activated, pre-synaptic inhibited enzyme breed [ AcIbEs AcIbE ] ; activated, post-synaptic enzyme ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; Breed Variable ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; turtles-own [ partner ] ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; SETUP ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; To setup clear-all reset-ticks random-seed 1 ;;; Environmental Control ;;; set dt 0.0005 set dtp 1 set tend 1 set time 0 set Vol 50000 set Diff 4e8 ;;; Configure Activators and Inhibitors ;;; if (inhibitor = "None") [ set kinh 0 set kage 0 set Inhibitors 0 ] if (inhibitor = "VX") [ set kinh 1.2e8 * 0.276763 ; converts L/mol*min to nm3/molecule*s set kage 0.019 * 2.7778e-4 ] ; converts h-1 to s-1 if (inhibitor = "VR") [ set kinh 4.4e8 * 0.276763 set kage 0.005 * 2.7778e-4 ] if (inhibitor = "GA") [ set kinh 7.4e6 * 0.276763 set kage .036 * 2.7778e-4 ] if (inhibitor = "GB") [ set kinh 2.7e7 * 0.276763 set kage 0.228 * 2.7778e-4 ] if (inhibitor = "GD") [ set kinh 9.2e7 * 0.276763 set kage 6.6 * 2.7778e-4 ] if (inhibitor = "GF") [ set kinh 4.9e8 * 0.276763 set kage 0.099 * 2.7778e-4 ] if (inhibitor = "Paraoxon") [ set kinh 1.2e6 * 0.276763 set kage 0.186 * 2.7778e-4 ] if (inhibitor = "Methamidophos") [ set kinh 1.9e3 * 0.276763 set kage 0.071 * 2.7778e-4 ] if (inhibitor = "DFP") [ set kinh 1.3e5 * 0.276763 set kage 0.221 * 2.7778e-4 ] if (inhibitor = "Tacrine") [ set kinh 5.7e7 * 1.660578 ; converts L/mol*s to nm3/molecule*s set kage 0 * 2.7778e-4 ] if (inhibitor = "Ambenonium") [ set kinh 4.0e9 * 1.660578 ; converts L/mol*s to nm3/molecule*s set kage 0 * 2.7778e-4 ] if (activator = "None") [ set kact 0 set k-act 0 set eps-on 1 set eps-off 1 set eps-cat 1 set eps-inh 1 set Activators 0 ] if (activator = "A9") [ set kact 1e7 set k-act 1 ; set eps-on 1 set eps-off 1 ; set eps-cat 1 ; set eps-inh 1 ] ;;; Agent Accounting Parameters ;;; set sumOpen 0 set sumAllOpen 0 set sumC 0 set nA 0 set nC 0 set nI Inhibitors set nAct Activators ;;; Receptor Parameters ;;; set k1 2.23e7 * 1.660578 ; converts L/mol*s to nm3/molecule*s set k-1 1330 set k2 4.7e8 * 1.660578 ; converts L/mol*s to nm3/molecule*s set k-2 13400 set b1 38 set a1 6000 set b2 51600 set a2 2460 set bD 65.2 set aD 775 ;;; Enzyme Parameters ;;; set ke 2.1e8 * 1.660578 set k-e 1.9e4 set kcat 6.8e3 ;;; Agent Creation ;;; set As0 200 set Ain 200 add-inhibitors add-activators create-Rs 200 create-tEns 25 create-bEns 25 create-As As0 ask Rs [ setxy random-xcor 0 set color red ] ask tEns [ setxy random-xcor 49 set color blue ] ask bEns [ setxy random-xcor 0 set color blue ] ask As [ setxy random-xcor 49 set color yellow ] ask AtEs [ set color magenta ] ask AbEs [ set color magenta ] ask ARs [ set color cyan ] ask A2Rs [ set color cyan ] ask AOs [ set color white ] ask A2Os [ set color white ] ask Acts [ set color grey ] ask Inhs [ set color brown ] ask turtles [ set partner nobody ] ;;; Parameter Printout ;;; output-print inhibitor output-type "kinh" output-type " " output-print kinh output-type "kage" output-type " " output-print kage ifelse (inhibitor = "None") [ output-print "No Inhibitor" ] [ output-print ((eps-inh * kinh * nI / Vol) / ((eps-inh * kinh * nI / Vol) + 1))] output-print " " output-print activator output-type "eps-on" output-type " " output-print eps-on output-type "eps-off" output-type " " output-print eps-off output-type "eps-cat" output-type " " output-print eps-cat output-type "eps-inh" output-type " " output-print eps-inh if (activator = "None") [ output-print "No Activator" ] output-print ((eps-on * ke * nI / Vol) / ((eps-on * ke * nI / Vol) + (eps-off * k-e))) output-print ((eps-cat * kcat) / ((eps-off * k-e) + (eps-cat * kcat))) end ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; RUNNING FUNCTIONS ;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; Main Go Loop ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; To go ask Ageds [ set color white ] ask ItEs [ set color white ] ask IbEs [ set color white ] ;;; Calculate Accounting Variables ;;; set time (time + dt) set sumC (sumC + (count (Cs))) set nA count ( As ) set sumOpen (count (AOs) + count (A2Os)) ;;; Partner removal ;;; ask turtles [ set partner nobody ] ;;; Execute commands ;;; ask Cs [die] ask Inhs [ move ] ask Acts [ move ] ask As [ move ] ask Inhs [ inhibitor-complex ] ask Acts [ activator-complex ] ask As [ substrate-complex ] ask A2Rs [ closed ] ask ARs [ closed ] ask A2Os [ open ] ask AOs [ open ] ask AtEs [ turnover ] ask AbEs [ turnover ] ask AcAtEs [ turnover ] ask AcAbEs [ turnover ] ask ItEs [ age ] ask IbEs [ age ] ask AcItEs [ age ] ask AcIbEs [ age ] ;;; Iteration ending ;;; tick if time > tend [ ; export-plot "Signals" "/users/richardchapleau/documents/projects/ache/modeling/NeuromuscularJunctionABM/outputs/signals.csv" ; export-plot "Products" "/users/richardchapleau/documents/projects/ache/modeling/NeuromuscularJunctionABM/outputs/products.csv" stop ] end ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; Substrate Procedures ;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; Substrate Move Loop ;;;;;;;;;;;;;;;;;;;;;;;;;;;; to move fd dt * Diff rt dt * Diff end ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; Substrate Binding Loop ;;;;;;;;;;;;;;;;;;;;;;;;; to substrate-complex if partner != nobody [ stop ] set partner one-of other turtles-here with [breed != As and partner = nobody] if partner = nobody [ stop ] if [partner] of partner != nobody [ stop ] ifelse ((partner != nobody and ([breed] of partner) = Rs) and ((random-float 1) < ((k1 * nA / Vol) / (((k1 * nA / Vol) + k-1))))) [ set (breed) ARs set color magenta ask partner [die] set partner nobody ] [ ifelse ((partner != nobody and ([breed] of partner) = ARs) and ((random-float 1) < ((k2 * nA / Vol) / (((k2 * nA / Vol) + k-2))))) [ set (breed) A2Rs set color magenta ask partner [die] set partner nobody ] [ ifelse ((partner != nobody and ([breed] of partner) = tEns) and ((random-float 1) < ((ke * nA / Vol) / (((ke * nA / Vol) + k-e))))) [ set (breed) AtEs set color green ask partner [die] set partner nobody ] [ ifelse ((partner != nobody and ([breed] of partner) = bEns) and ((random-float 1) < ((ke * nA / Vol) / (((ke * nA / Vol) + k-e))))) [ set (breed) AbEs set color green ask partner [die] set partner nobody ] [ ifelse ((partner != nobody and ([breed] of partner) = ActEs) and ((random-float 1) < ((eps-on * ke * nA / Vol) / ((eps-on * ke * nA / Vol) + (eps-off * k-e))))) [ set (breed) AcAtEs set color green ask partner [die] set partner nobody ] [ ifelse ((partner != nobody and ([breed] of partner) = AcbEs) and ((random-float 1) < ((eps-on * ke * nA / Vol) / ((eps-on * ke * nA / Vol) + (eps-off * k-e))))) [ set (breed) AcAbEs set color green ask partner [die] set partner nobody ] [ ask partner [ set partner nobody ] set partner nobody ] ] ] ] ] ] end ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; Receptor Procedures ;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; Closed Receptor Loop ;;;;;;;;;;;;;;;;;;;;;;;;;;; to closed ifelse breed = A2Rs [ ifelse ((random-float 1) < (dt * bD / (dt * (bD + aD + k-2 + b2 + a2 + (nA * k2 / Vol))))) [ set (breed) A2Ds ] [ ifelse ((random-float 1) < (dt * k-2 / (dt * (bD + aD + k-2 + b2 + a2 + (nA * k2 / Vol))))) [ set (breed) ARs hatch-As 1 ] [ ifelse ((random-float 1) < (dt * k1 / (dt * (bD + aD + k-2 + b2 + a2 + (nA * k2 / Vol))))) [ set (breed) A2Os ] [stop ] ] ] ] [ if breed = ARs [ ifelse ((random-float 1) < (dt * b1 / (dt * (a1 + b1 + k-1 + (nA * k1 / Vol))))) [ set (breed) AOs ] [ ifelse ((random-float 1) < (dt * k-1 / (dt * (a1 + b1 + k-1 + (nA * k1 / Vol))))) [ set (breed) Rs hatch-As 1 ] [ stop ] ] ] ] end ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; Open Receptor Loop ;;;;;;;;;;;;;;;;;;;;;;;;;;;;; to open ifelse breed = A2Os [ ifelse ((random-float 1) < (a2 / (a2 + b2))) [ set (breed) A2Rs ] [ stop ] ] [ if breed = AOs [ ifelse ((random-float 1) < (a1 / (a1 + b1))) [ set (breed) ARs ] [ stop ] ] ] end ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; Enzyme Procedures ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; Enzyme Turnover Loop ;;;;;;;;;;;;;;;;;;;;;;;;;;; to turnover ifelse breed = AtEs [ ifelse (((dt * kcat) / (dt * (k-e + kcat))) > (random-float 1)) [ set (breed) tEns set partner nobody hatch-Cs 1 ] [ stop ] ] [ ifelse breed = AbEs [ ifelse (((dt * kcat) / (dt * (k-e + kcat))) > (random-float 1)) [ set (breed) bEns set partner nobody hatch-Cs 1 ] [ stop ] ] [ ifelse breed = AcAtEs [ ifelse (((dt * eps-cat * kcat) / (dt * ((eps-off * k-e) + (eps-cat * kcat)))) > (random-float 1)) [ set (breed) ActEs set partner nobody hatch-Cs 1 ] [ stop ]] [ ifelse breed = AcAbEs [ if (((dt * eps-cat * kcat) / (dt * ((eps-off * k-e) + (eps-cat * kcat)))) > (random-float 1)) [ set (breed) AcbEs set partner nobody hatch-Cs 1 ] ] [ stop ] ] ] ] end ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; Enzyme Aging Loop ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; to age ifelse breed = ItEs [ ifelse ((kage / (1 + (kinh * nI / Vol) + kage)) > (random-float 1)) [ set (breed) Ageds set partner nobody ] [ if ((random-float 1) < (1 / (1 + (kinh * nI / Vol) + kage))) [ set (breed) tEns set partner nobody hatch-Inhs 1 ] ] ] [ ifelse ((kage / (1 + (kinh * nI / Vol) + kage)) > (random-float 1)) [ set (breed) Ageds set partner nobody ] [ if ((random-float 1) < (1 / (1 + (kinh * nI / Vol) + kage))) [ set (breed) bEns set partner nobody hatch-Inhs 1 ] ] ] ifelse ((breed = AcItEs) and ((kage / (1 + (eps-inh * kinh * nI / Vol) + kage)) > (random-float 1))) [ set (breed) Ageds set partner nobody ] [ if ((random-float 1) < (1 / (1 + (eps-inh * kinh * nI / Vol) + kage))) [ set (breed) ActEs set partner nobody ] ] ifelse ((breed = AcIbEs) and ((kage / (1 + (eps-inh * kinh * nI / Vol) + kage)) > (random-float 1))) [ set (breed) Ageds set partner nobody ] [ if ((random-float 1) < (1 / (1 + (eps-inh * kinh * nI / Vol) + kage))) [ set (breed) AcbEs set partner nobody ] ] end ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; Inhibitor Procedures ;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; Inhibitor Addition Loop ;;;;;;;;;;;;;;;;;;;;;;;; to add-inhibitors create-Inhs Inhibitors ask Inhs [ setxy random-xcor random-ycor set color pink set partner nobody ] end ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; Enzyme Inhibition Loop ;;;;;;;;;;;;;;;;;;;;;;;;; to inhibitor-complex if partner != nobody [ stop ] set partner one-of (other turtles-here with [breed != As]) if partner = nobody [ stop ] ifelse ((partner != nobody and ([breed] of partner) = tEns) and ((random-float 1) < ((kinh * nI / Vol) / ((kinh * nI / Vol) + 1)))) [ set (breed) ItEs set color magenta ask partner [die] set partner nobody ] [ ifelse ((partner != nobody and ([breed] of partner) = bEns) and ((random-float 1) < ((kinh * nI / Vol) / ((kinh * nI / Vol) + 1)))) [ set (breed) IbEs set color magenta ask partner [die] set partner nobody ] [ ifelse ((partner != nobody and ([breed] of partner) = ActEs) and ((random-float 1) < ((eps-inh * kinh * nI / Vol) / ((eps-inh * kinh * nI / Vol) + 1)))) [ set (breed) AcItEs set color magenta ask partner [die] set partner nobody ] [ ifelse ((partner != nobody and ([breed] of partner) = AcbEs) and ((random-float 1) < ((eps-inh * kinh * nI / Vol) / ((eps-inh * kinh * nI / Vol) + 1)))) [ set (breed) AcIbEs set color magenta ask partner [die] set partner nobody ] [ ask partner [ set partner nobody ] set partner nobody ] ] ] ] end ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; Activator Procedures ;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; Activator Additon Loop ;;;;;;;;;;;;;;;;;;;;;;;;; to add-activators create-Acts Activators ask Acts [ setxy random-xcor random-ycor set color cyan set partner nobody ] end ;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; Enzyme Activation Loop ;;;;;;;;;;;;;;;;;;;;;;;;; to activator-complex if partner != nobody [ stop ] set partner one-of (other turtles-here with [breed != As]) if partner = nobody [ stop ] if ([breed] of partner = As) [ ask partner [ set partner nobody] set partner nobody stop ] if ([breed] of partner = Inhs) [ ask partner [ set partner nobody] set partner nobody stop ] ifelse ((partner != nobody and ([breed] of partner) = tEns) and ((random-float 1) < ((dt * kact * nAct / Vol) / (dt * ((kact * nAct / Vol) + k-act))))) [ set (breed) ActEs set color sky ask partner [ die ] set partner nobody ] [ ifelse ((([breed] of partner) = bEns) and ((random-float 1) < ((dt * kact * nAct / Vol) / (dt * ((kact * nAct / Vol) + k-act))))) [ set (breed) AcbEs set color sky ask partner [ die ] set partner nobody ] [ ask partner [ set partner nobody ] set partner nobody ] ] end @#$#@#$#@ GRAPHICS-WINDOW 171 10 1681 791 -1 -1 15.0 1 10 1 1 1 0 1 0 1 0 99 0 49 0 0 1 ticks 30.0 BUTTON 19 35 82 68 Start go T 1 T OBSERVER NIL NIL NIL NIL 1 BUTTON 19 70 85 103 Setup setup NIL 1 T OBSERVER NIL NIL NIL NIL 1 BUTTON 19 105 124 138 Inject Signal create-A-ins Ain\nask A-ins [\nsetxy random-xcor 49\nset color yellow\nset partner nobody\nset (breed) As\n] NIL 1 T OBSERVER NIL NIL NIL NIL 1 PLOT 678 179 1090 428 Signals time Total Signals 0.0 1.0 0.0 100.0 false true "" "" PENS "Open Channels" 1.0 0 -16777216 true "" "plotxy time sumOpen" CHOOSER 9 285 157 330 inhibitor inhibitor "None" "VX" "VR" "GA" "GB" "GD" "GF" "Paraoxon" "Methamidophos" "DFP" "Tacrine" "Ambenonium" 6 INPUTBOX 9 333 164 393 Inhibitors 50 1 0 Number INPUTBOX 11 494 166 554 Activators 15 1 0 Number BUTTON 19 140 147 173 Inject Inhibitors create-Inhs Inhibitors\nask Inhs [\nsetxy random-xcor random-ycor\nset color pink\nset partner nobody\n] NIL 1 T OBSERVER NIL NIL NIL NIL 1 BUTTON 19 175 151 208 Inject Activators create-Acts Activators\nask Acts [\nsetxy random-xcor random-ycor\nset color cyan\nset partner nobody\n] NIL 1 T OBSERVER NIL NIL NIL NIL 1 CHOOSER 11 446 149 491 Activator Activator "None" "A9" 1 PLOT 341 180 669 390 Products NIL NIL 0.0 1.0 0.0 210.0 false true "" "" PENS "Cs" 1.0 0 -13840069 true "" "plotxy time sumC" OUTPUT 15 553 160 781 12 INPUTBOX 214 453 449 513 eps-inh 0.0971 1 0 Number INPUTBOX 455 520 610 580 eps-cat 1 1 0 Number INPUTBOX 455 456 610 516 eps-on 1 1 0 Number @#$#@#$#@ ## WHAT IS IT? (a general understanding of what the model is trying to show or explain) ## HOW IT WORKS (what rules the agents use to create the overall behavior of the model) ## HOW TO USE IT (how to use the model, including a description of each of the items in the Interface tab) ## THINGS TO NOTICE (suggested things for the user to notice while running the model) ## THINGS TO TRY (suggested things for the user to try to do (move sliders, switches, etc.) with the model) ## EXTENDING THE MODEL (suggested things to add or change in the Code tab to make the model more complicated, detailed, accurate, etc.) ## NETLOGO FEATURES (interesting or unusual features of NetLogo that the model uses, particularly in the Code tab; or where workarounds were needed for missing features) ## RELATED MODELS (models in the NetLogo Models Library and elsewhere which are of related interest) ## CREDITS AND REFERENCES (a reference to the model's URL on the web if it has one, as well as any other necessary credits, citations, and links) @#$#@#$#@ default true 0 Polygon -7500403 true true 150 5 40 250 150 205 260 250 airplane true 0 Polygon -7500403 true true 150 0 135 15 120 60 120 105 15 165 15 195 120 180 135 240 105 270 120 285 150 270 180 285 210 270 165 240 180 180 285 195 285 165 180 105 180 60 165 15 arrow true 0 Polygon -7500403 true true 150 0 0 150 105 150 105 293 195 293 195 150 300 150 box false 0 Polygon -7500403 true true 150 285 285 225 285 75 150 135 Polygon -7500403 true true 150 135 15 75 150 15 285 75 Polygon -7500403 true true 15 75 15 225 150 285 150 135 Line -16777216 false 150 285 150 135 Line -16777216 false 150 135 15 75 Line -16777216 false 150 135 285 75 bug true 0 Circle -7500403 true true 96 182 108 Circle -7500403 true true 110 127 80 Circle -7500403 true true 110 75 80 Line -7500403 true 150 100 80 30 Line -7500403 true 150 100 220 30 butterfly true 0 Polygon -7500403 true true 150 165 209 199 225 225 225 255 195 270 165 255 150 240 Polygon -7500403 true true 150 165 89 198 75 225 75 255 105 270 135 255 150 240 Polygon -7500403 true true 139 148 100 105 55 90 25 90 10 105 10 135 25 180 40 195 85 194 139 163 Polygon -7500403 true true 162 150 200 105 245 90 275 90 290 105 290 135 275 180 260 195 215 195 162 165 Polygon -16777216 true false 150 255 135 225 120 150 135 120 150 105 165 120 180 150 165 225 Circle -16777216 true false 135 90 30 Line -16777216 false 150 105 195 60 Line -16777216 false 150 105 105 60 car false 0 Polygon -7500403 true true 300 180 279 164 261 144 240 135 226 132 213 106 203 84 185 63 159 50 135 50 75 60 0 150 0 165 0 225 300 225 300 180 Circle -16777216 true false 180 180 90 Circle -16777216 true false 30 180 90 Polygon -16777216 true false 162 80 132 78 134 135 209 135 194 105 189 96 180 89 Circle -7500403 true true 47 195 58 Circle -7500403 true true 195 195 58 circle false 0 Circle -7500403 true true 0 0 300 circle 2 false 0 Circle -7500403 true true 0 0 300 Circle -16777216 true false 30 30 240 cow false 0 Polygon -7500403 true true 200 193 197 249 179 249 177 196 166 187 140 189 93 191 78 179 72 211 49 209 48 181 37 149 25 120 25 89 45 72 103 84 179 75 198 76 252 64 272 81 293 103 285 121 255 121 242 118 224 167 Polygon -7500403 true true 73 210 86 251 62 249 48 208 Polygon -7500403 true true 25 114 16 195 9 204 23 213 25 200 39 123 cylinder false 0 Circle -7500403 true true 0 0 300 dot false 0 Circle -7500403 true true 90 90 120 face happy false 0 Circle -7500403 true true 8 8 285 Circle -16777216 true false 60 75 60 Circle -16777216 true false 180 75 60 Polygon -16777216 true false 150 255 90 239 62 213 47 191 67 179 90 203 109 218 150 225 192 218 210 203 227 181 251 194 236 217 212 240 face neutral false 0 Circle -7500403 true true 8 7 285 Circle -16777216 true false 60 75 60 Circle -16777216 true false 180 75 60 Rectangle -16777216 true false 60 195 240 225 face sad false 0 Circle -7500403 true true 8 8 285 Circle -16777216 true false 60 75 60 Circle -16777216 true false 180 75 60 Polygon -16777216 true false 150 168 90 184 62 210 47 232 67 244 90 220 109 205 150 198 192 205 210 220 227 242 251 229 236 206 212 183 fish false 0 Polygon -1 true false 44 131 21 87 15 86 0 120 15 150 0 180 13 214 20 212 45 166 Polygon -1 true false 135 195 119 235 95 218 76 210 46 204 60 165 Polygon -1 true false 75 45 83 77 71 103 86 114 166 78 135 60 Polygon -7500403 true true 30 136 151 77 226 81 280 119 292 146 292 160 287 170 270 195 195 210 151 212 30 166 Circle -16777216 true false 215 106 30 flag false 0 Rectangle -7500403 true true 60 15 75 300 Polygon -7500403 true true 90 150 270 90 90 30 Line -7500403 true 75 135 90 135 Line -7500403 true 75 45 90 45 flower false 0 Polygon -10899396 true false 135 120 165 165 180 210 180 240 150 300 165 300 195 240 195 195 165 135 Circle -7500403 true true 85 132 38 Circle -7500403 true true 130 147 38 Circle -7500403 true true 192 85 38 Circle -7500403 true true 85 40 38 Circle -7500403 true true 177 40 38 Circle -7500403 true true 177 132 38 Circle -7500403 true true 70 85 38 Circle -7500403 true true 130 25 38 Circle -7500403 true true 96 51 108 Circle -16777216 true false 113 68 74 Polygon -10899396 true false 189 233 219 188 249 173 279 188 234 218 Polygon -10899396 true false 180 255 150 210 105 210 75 240 135 240 house false 0 Rectangle -7500403 true true 45 120 255 285 Rectangle -16777216 true false 120 210 180 285 Polygon -7500403 true true 15 120 150 15 285 120 Line -16777216 false 30 120 270 120 leaf false 0 Polygon -7500403 true true 150 210 135 195 120 210 60 210 30 195 60 180 60 165 15 135 30 120 15 105 40 104 45 90 60 90 90 105 105 120 120 120 105 60 120 60 135 30 150 15 165 30 180 60 195 60 180 120 195 120 210 105 240 90 255 90 263 104 285 105 270 120 285 135 240 165 240 180 270 195 240 210 180 210 165 195 Polygon -7500403 true true 135 195 135 240 120 255 105 255 105 285 135 285 165 240 165 195 line true 0 Line -7500403 true 150 0 150 300 line half true 0 Line -7500403 true 150 0 150 150 pentagon false 0 Polygon -7500403 true true 150 15 15 120 60 285 240 285 285 120 person false 0 Circle -7500403 true true 110 5 80 Polygon -7500403 true true 105 90 120 195 90 285 105 300 135 300 150 225 165 300 195 300 210 285 180 195 195 90 Rectangle -7500403 true true 127 79 172 94 Polygon -7500403 true true 195 90 240 150 225 180 165 105 Polygon -7500403 true true 105 90 60 150 75 180 135 105 plant false 0 Rectangle -7500403 true true 135 90 165 300 Polygon -7500403 true true 135 255 90 210 45 195 75 255 135 285 Polygon -7500403 true true 165 255 210 210 255 195 225 255 165 285 Polygon -7500403 true true 135 180 90 135 45 120 75 180 135 210 Polygon -7500403 true true 165 180 165 210 225 180 255 120 210 135 Polygon -7500403 true true 135 105 90 60 45 45 75 105 135 135 Polygon -7500403 true true 165 105 165 135 225 105 255 45 210 60 Polygon -7500403 true true 135 90 120 45 150 15 180 45 165 90 sheep false 15 Circle -1 true true 203 65 88 Circle -1 true true 70 65 162 Circle -1 true true 150 105 120 Polygon -7500403 true false 218 120 240 165 255 165 278 120 Circle -7500403 true false 214 72 67 Rectangle -1 true true 164 223 179 298 Polygon -1 true true 45 285 30 285 30 240 15 195 45 210 Circle -1 true true 3 83 150 Rectangle -1 true true 65 221 80 296 Polygon -1 true true 195 285 210 285 210 240 240 210 195 210 Polygon -7500403 true false 276 85 285 105 302 99 294 83 Polygon -7500403 true false 219 85 210 105 193 99 201 83 square false 0 Rectangle -7500403 true true 30 30 270 270 square 2 false 0 Rectangle -7500403 true true 30 30 270 270 Rectangle -16777216 true false 60 60 240 240 star false 0 Polygon -7500403 true true 151 1 185 108 298 108 207 175 242 282 151 216 59 282 94 175 3 108 116 108 target false 0 Circle -7500403 true true 0 0 300 Circle -16777216 true false 30 30 240 Circle -7500403 true true 60 60 180 Circle -16777216 true false 90 90 120 Circle -7500403 true true 120 120 60 tree false 0 Circle -7500403 true true 118 3 94 Rectangle -6459832 true false 120 195 180 300 Circle -7500403 true true 65 21 108 Circle -7500403 true true 116 41 127 Circle -7500403 true true 45 90 120 Circle -7500403 true true 104 74 152 triangle false 0 Polygon -7500403 true true 150 30 15 255 285 255 triangle 2 false 0 Polygon -7500403 true true 150 30 15 255 285 255 Polygon -16777216 true false 151 99 225 223 75 224 truck false 0 Rectangle -7500403 true true 4 45 195 187 Polygon -7500403 true true 296 193 296 150 259 134 244 104 208 104 207 194 Rectangle -1 true false 195 60 195 105 Polygon -16777216 true false 238 112 252 141 219 141 218 112 Circle -16777216 true false 234 174 42 Rectangle -7500403 true true 181 185 214 194 Circle -16777216 true false 144 174 42 Circle -16777216 true false 24 174 42 Circle -7500403 false true 24 174 42 Circle -7500403 false true 144 174 42 Circle -7500403 false true 234 174 42 turtle true 0 Polygon -10899396 true false 215 204 240 233 246 254 228 266 215 252 193 210 Polygon -10899396 true false 195 90 225 75 245 75 260 89 269 108 261 124 240 105 225 105 210 105 Polygon -10899396 true false 105 90 75 75 55 75 40 89 31 108 39 124 60 105 75 105 90 105 Polygon -10899396 true false 132 85 134 64 107 51 108 17 150 2 192 18 192 52 169 65 172 87 Polygon -10899396 true false 85 204 60 233 54 254 72 266 85 252 107 210 Polygon -7500403 true true 119 75 179 75 209 101 224 135 220 225 175 261 128 261 81 224 74 135 88 99 wheel false 0 Circle -7500403 true true 3 3 294 Circle -16777216 true false 30 30 240 Line -7500403 true 150 285 150 15 Line -7500403 true 15 150 285 150 Circle -7500403 true true 120 120 60 Line -7500403 true 216 40 79 269 Line -7500403 true 40 84 269 221 Line -7500403 true 40 216 269 79 Line -7500403 true 84 40 221 269 wolf false 0 Polygon -16777216 true false 253 133 245 131 245 133 Polygon -7500403 true true 2 194 13 197 30 191 38 193 38 205 20 226 20 257 27 265 38 266 40 260 31 253 31 230 60 206 68 198 75 209 66 228 65 243 82 261 84 268 100 267 103 261 77 239 79 231 100 207 98 196 119 201 143 202 160 195 166 210 172 213 173 238 167 251 160 248 154 265 169 264 178 247 186 240 198 260 200 271 217 271 219 262 207 258 195 230 192 198 210 184 227 164 242 144 259 145 284 151 277 141 293 140 299 134 297 127 273 119 270 105 Polygon -7500403 true true -1 195 14 180 36 166 40 153 53 140 82 131 134 133 159 126 188 115 227 108 236 102 238 98 268 86 269 92 281 87 269 103 269 113 x false 0 Polygon -7500403 true true 270 75 225 30 30 225 75 270 Polygon -7500403 true true 30 75 75 30 270 225 225 270 @#$#@#$#@ NetLogo 5.0.4 @#$#@#$#@ @#$#@#$#@ @#$#@#$#@ setup go sumOpen setup go sumOpen setup go sumOpen setup go sumOpen setup go sumOpen setup go sumOpen setup go sumOpen setup go sumOpen setup go sumOpen @#$#@#$#@ @#$#@#$#@ default 0.0 -0.2 0 0.0 1.0 0.0 1 1.0 0.0 0.2 0 0.0 1.0 link direction true 0 Line -7500403 true 150 150 90 180 Line -7500403 true 150 150 210 180 @#$#@#$#@ 0 @#$#@#$#@